Nobilis Ma5+Clone30 is a live vaccine used for the immunization of chickens against Newcastle (ND) and Infectious Bronchitis (IB) (Massachusetts serotype, Ma5 strain). 

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Composition
Amount of active ingredient in one dose: 
Live IB virus Ma5 strain:   ³  3.0 log10 EID  50
Live ND virus Clone 30 strain:   ³  6.0 log10 EID  50

Formulation
Lyophilized

Target species
Chickens

Indications:
Used for protection against IB disease and Newcastle disease caused by the Massachusetts strain or strains with serologically similar characteristics.

There are no contraindications
.

The vaccination program
can be easily applied to chicks that are 1 day old and older. 
The appropriate time and method of application may vary depending on local conditions, so a veterinarian should be consulted.

Dosage
One dose for each chick.

Method of application:
It can be administered via drinking water, spray or nose eye drops.

A. Spray method 
The vaccine should be opened under cold water that does not contain chlorine and iron. The tools to be used for spray application should not be corroded and should not contain any residue (disinfectant etc.). The water containing the vaccine is applied to the determined number of animals from a height of 30-40 cm. 
For one-day-old chicks, 0.25 liters of water is sufficient for 1000 chicks, thick droplet sprays should be used. 
For older animals, 1000 doses of vaccine should be dissolved in 1 liter of water and fine droplet spray should be used. (Aerosol generators known to be safe for animals should be used)

B. Nose / Eye drop method
The vaccine should be dissolved in physiological saline (usually 30 ml for 1000 doses) and applied to the nose or eye from a height of a few centimeters using standard droppers. It should be ensured that the drops administered into the nose are taken. 
Note. There is a special diluent for this application.

C. Drinking water method
Open the vaccine bottle under cool water that does not contain iron and chlorine, add 2 grams of skimmed milk powder to 1 liter of water so that the virus activity is preserved for a long time. Make sure that the water to which the vaccine has been added is consumed within 2 hours. Depending on the weather conditions, animals may be left without water for a certain period before vaccination. There should be a sufficient number of waterers, these waterers should be clean and should not contain detergent and disinfectant residues. Depending on the age of the animal to be vaccinated, 1000 doses of vaccine should be dissolved in a maximum of 40 liters of water. 
Vaccination should be done early in the morning, this is the period when water consumption and coolness are the longest on hot days. If a large herd is to be vaccinated, it is recommended that the vaccine be divided. If the vaccination is to be done through general nipple drinkers or dosing units, great care should be taken. The next higher dose should be selected for animal numbers between the standard doses. 
Note. Especially in young animals, the spray and nose/eye drop methods are the methods that give the best results from the methods described above.

Legal purification period
0 days

Presentation 
In vials containing 1000, 2500 or 5000 doses of pellets each.

Storage conditions: 
Store at 2-8  °  C, protected from sunlight.

Warnings

• Only healthy animals should be vaccinated.
• Disinfect your hands and equipment after vaccination.
• Opened vaccines should be consumed within 2 hours.

Other information

• In case of contact with eyes, it causes conjunctivitis in the applicator.
• Precautions should be taken against the spread of the vaccine virus (e.g. face mask should be used).
• Dispose of empty or slightly used bottles in accordance with the law.
• The vaccine virus spreads rapidly in chicks that come into contact with it.